Among Class I alleles, HLA-B*35:03:01:03 (p = 0.0004, OR = 7.42) and HLA-C*04:01:01:14 (p = 0.0002, OR = 3.50) were significantly more frequent in MS patients compared to controls (pc < 0.05, Bonferroni-adjusted). This evidence concerns the gene HLA-C and myeloid sarcoma.