It further inhibits multiple steps of VEGF-induced cell proliferation, migration, invasion, and tube formation; Active alkaloids and its derivatives present in Catharanthus roseus (L.)are well known for their significant curative effects against human neoplasms; Glycosides and its derivative present in Centella asiatica L. has shown to decrease the viability of HepG2 cells in the case of liver cancer and Saponins, steroids and its derivatives present in Panax ginseng has demonstrated antitumor potential and a potential to induce cell death. Here, VEGFA is linked to neoplasm.