Since EMT of RPE cells occurs in diseases of the chorioretinal interface, such as AMD or proliferative vitreoretinopathy [23,24], and the functions of galectin-3 depend on several circumstances like its localization, the cell type, or glycosylation of the transmembrane proteins, we investigated the role of endogenous galectin-3 in ARPE-19 cells. Here, LGALS3 is linked to proliferative vitreoretinopathy.