Since TTF-1 can inhibit TGF-β-mediated EMT and restore the epithelial phenotype in lung adenocarcinoma cells [38], it is tempting to speculate that the decreased expression of galectin-3 leads to a reduced activity of transcription factors, such as TTF-1, which are essential to maintain the epithelial phenotype of RPE cells. The gene discussed is LGALS3; the disease is lung adenocarcinoma.