In contrast, ALI cultures from a CF patient homozygous for F508del (p.Phe508del) variant) demonstrated restored apical localization of CFTR upon treatment with modulator therapy (elexacaftor/tezacaftor) as shown by enhanced CFTR staining (green) at the apical membrane (Figure 7B). The gene discussed is CFTR; the disease is cystic fibrosis.