NLRP3 and hypertensive nephropathy: Experiments have revealed that NLRP3 activation in immune cells (macrophages and dendritic cells) and renal resident cells, such as the tubular epithelium, is prevalent and is responsible for acute [146,147,148] and chronic kidney injury [145,149,150], including hypertensive nephropathy [9,151,152], through both canonical inflammasome activation and non-canonical pathways of mitochondrial stress and pyroptosis [153].