TREM1 and colitis: Similarly, macrophages in inflamed intestines have been demonstrated to express TREM-1 (triggering receptor expressed on myeloid cells-1), which augments their proinflammatory responses [292], likely through the mTORC1 pathway [184], whereas TREM-1 blockage restores impaired macrophage autophagic activity to suppress DSS-induced colitis in mice [293].