On the other hand, mTORC1 has been proposed to mediate TNF-induced IL-10 expression and the STAT3-initiated cascade in synovial macrophages [263], whereas pharmacological blockage of Cot/Tpl-2/MAP3K8 in macrophages has been suggested to induce therapeutic effects in various autoimmune disorders [264]. The gene discussed is MAP3K8; the disease is autoimmune disease.