MTOR and allergic asthma: However, particulate matter 2.5 (PM2.5), an environmental pollutant, has been proved to exert detrimental adjuvant effect, exacerbating allergic asthma in an animal model [235], and its action was shown to synergize with Pseudomonas aeruginosa to suppress antimicrobial activity of alveolar macrophages by increasing mTOR signaling [236], along with promoting pulmonary inflammation due to stimulation of macrophage mTOR pathway by particular matter itself [237], resulting in autophagy impairment [238].