AKT1 and tuberous sclerosis: mTOR has been shown to play an important role in various signaling pathways, such as PI3K/Akt (phosphatidylinositol 3-kinase/Akt) pathway, the LKBL/AMPK pathway, the TSC1/TSC2/Rheb system (a protein complex associated with tuberous sclerosis), as well as processes dependent on VAM6 and Rag GTPases, and many others [15].