CASP3 and gastric cancer: In gastric cancer (GC), the activation of pyroptosis-related genes (PRGs) such as GSDMD and GSDME is linked to favorable prognosis, while agents like famotidine, simvastatin, icariin, and diosbulbin-B trigger NLRP3 or caspase-3-mediated pyroptosis [64,65,66,67].