In the current research, we are the first to show that quinoline alkaloids fumiquinazolines F and G produced by the fungus P. thymicola possess anti-cancer properties against TNBC cells by modulating protein levels of EMT-related markers such as E-cadherin, vimentin, and CD44, causing MDA-MB-231 mesenchymal cells to revert to the epithelial phenotype seen in less malignant neoplasms. The gene discussed is CD44; the disease is cancer.