CD44 and hepatocellular carcinoma: However, MG132-induced proteasome blockade results in an increase in CD44 protein in epithelial cells such as T24T (invasive human transitional cell carcinoma of the bladder) [39], HuH-7 (human hepatocarcinoma), and PLC/PRF/5 (human hepatoma) [40], implying that, in these cells, proteosomes may play a role in the regulation of CD44 stability.