IL1B and autoimmune polyendocrinopathy: Additionally, Wakayama et al. compared the cellular and cytokine outputs of APS and LP-PRP and found significantly higher concentrations of platelets, leukocytes, interleukin 1 receptor antagonist (IL-1Ra), soluble tumor necrosis factor receptor type II (sTNF-RII), interleukin 1β (IL-1β), and the ratio of IL-1Ra/IL-1 β in APS, whereas the platelet derived growth factor subunit BB (PDGF-BB) was higher in LP-PRP [12].