DNMT1 and breast cancer: In this context, dietary genistein was shown to protect rats from chemically induced mammary tumors in a dose-dependent manner through the inhibition of DNMT activity; green tea epigallocatechin-3-gallate (EGCG) decreases DNMT protein levels and reduces 5-methyl cytosine content, thus exerting both cancer prevention and antidiabetic properties [64,65].