Consistent with this hypothesis, saffron has been already reported to drive a senescence-delaying effects in aging mice [66], to prevent skin aging induced by UV exposure [67], and to reduce age-related retinal degeneration in bright continuous light exposure rat models [68]; nevertheless, in vitro and in vivo studies are necessary to specifically address the saffron–DNMT hypothesis in aging. The gene discussed is DNMT1; the disease is skin aging.