ESRRA and age: On the other hand, senomorphics of biological origin such as resveratrol, curcumin, vitamin E, and genistein have shown positive effects in counteracting age-related musculoskeletal decline by regulating key signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), mTOR, sirtuin 1 (SIRT1), and estrogen-related receptor alpha (ERRα) [10,11].