Compared with the FE-alone group, intravenous injection of MCC950 (10 mg/kg, I.V.)significantly reduced FE-induced pulmonary edema from 81.12% ± 1.34% to 78.13% ± 0.65%, indicating that NLRP3 mediates FE-induced pulmonary edema (Figure 2C). Here, NLRP3 is linked to pulmonary edema.