By combining supervised and unsupervised learning approaches across nine transcriptomics datasets, several genes affected by DNA methylation in GBM (ASPM, CCNB2, CDK1, AURKA, TOP2A, CHEK1, CDCA8, MCM10, and RAD51AP1), have been identified, suggesting potential biomarkers for diagnosis and targets for therapy [60]. The gene discussed is TOP2A; the disease is glioblastoma.