Specific lncRNAs, such as HOTAIR (which promotes AML progression by regulating gene expression), MALAT1A (associated with poor prognosis), MEG3 (a tumor suppressor often downregulated in AML), and LINC00152 (implicated in AML cell proliferation and survivals), are crucial for AML prognosis [81,82,85], offering promising avenues for improving patient outcomes. The gene discussed is HOTAIR; the disease is acute myeloid leukemia.