APOE and Alzheimer disease: We downloaded three proteins associated with early onset AD (EOAD): amyloid-beta precursor protein (Gene APP), presenilin-1 (Gene PSEN1), and presenilin-2 (Gene PSEN2); and three proteins associated with late onset AD (LOAD): apolipoprotein E (Gene APOE), disintegrin and metalloproteinase domain-containing protein 10 (Gene ADAM10), and phospholipid-transporting ATPase ABCA7 (Gene ABCA7).