The duration of PTSD also influences these correlations; for instance, the correlation between IRE1 and CECS Anger shifts from ρ = −0.245 in Past PTSD ≤ 5y to ρ = −0.312 in Past PTSD > 5y (z = −0.31, p = 0.76), showing no significant change, but the overall pattern implies that chronic PTSD may slightly strengthen negative associations between biomarkers and emotional suppression. The gene discussed is ERN1; the disease is post-traumatic stress disorder.