Several genes, including SRY-Box Transcription Factor 11 (SOX11) and Heat Shock Protein Beta-9 (HSPB9), have shown consistent methylation differences between bladder cancer patients and healthy controls, with detection methods such as bisulfite pyrosequencing and quantitative methylation-specific PCR (qMSP) proving useful in clinical stratification [2,11]. The gene discussed is SOX11; the disease is urinary bladder cancer.