NFE2L2 and isolated hemihyperplasia: Figure 4A,B show the top 20 activated and inhibited pathways in the IH group compared to controls, respectively. Activated pathways included mitochondrial dysfunction (−log10 (p) = 19.6, Z-score = 4.838), while inhibited pathways included the KEAP1-NFE2L2 antioxidant pathway (−log10 (p) = 5.74, Z-score = −5.303). For the IH vs. SH comparison, the top 20 altered pathways are shown in Figure 4C, D, with the KEAP1-NFE2L2 pathway inhibited (−log10 (p) = 4.33, Z-score = −3.441).