TNF and diabetes mellitus: The silver complex nanoparticles with Resina draconis extract and R. rosea extract loaded onto polyurethane nanofibers reached about 87.92% wound closure in diabetic mice, enhanced the migration and proliferation of fibroblasts, reduced the increased thickness of regenerated epidermis caused by diabetes, and the high expression and high lipid peroxidation levels of IL-1 b, IL-6, TNF a, iNOS, and MMP-9, and raise the low expression of VEGF [49].