Zn supplementation reduces the risk of developing osteopenia or osteoporosis;Zn aspartate and Zn citratelower the levels of rheumatoid factor (RF), antibodies against citrullinated proteins (ACPA) and C-reactive protein (CRP), and reduce joint erosion and osteophyte formation;Zn nanoparticles reduce M1 macrophage infiltration into the synovial membrane, levels of IL-1 and TNF-α, and ACPA;. This evidence concerns the gene IL1B and osteoporosis.