One study suggests that deficiency and reduced expression of the Zn finger protein A20 (a protein of which Zn is an integral component) in RA synovial tissues may lead to increased pyroptosis in RA synoviocyte-like fibroblasts through dysregulation of the NLR family pyrin domain containing 3 (NLRP3)/caspase-1 pathway [141]. The gene discussed is CASP1; the disease is rheumatoid arthritis.