After viral infection, the expressions of many detoxification-related genes were upregulated, such as cytochrome P450 9e2 (CYP9E2), cytochrome P450 6B7 (CYP6B7), cytochrome P450 6B6 (CYP6B6), glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and multidrug resistance-associated protein 4-like (MRP4/ABCC4). Here, HPGDS is linked to viral infectious disease.