Finally, a meta-analysis of six GEO series plus TCGA-PRAD, SU2C/PCF, and MSK-IMPACT RNA-seq yielded two consensus signatures: PCa-sig (primary vs. metastatic, AUC = 0.93) and NE-sig (AR-positive vs. neuro-endocrine CRPC, AUC = 0.91). Here, AR is linked to posterior cortical atrophy.