SIRT1 and neoplasm: Our findings demonstrate that the combined administration of SC with antineoplastic agents inhibits proliferation and enhances apoptosis in cytarabine-resistant WEHI-CR50 cells by decreasing the expression of genes involved in chemoresistance (SIRT1 and MDR1), increasing the expression of ENT1 and dCK, molecules involved in the uptake and metabolism of Ara-C, and increasing the survival of WEHI-CR50 tumor-bearing mice.