SIRT1 and acute myeloid leukemia: Additionally, SIRT1 (silent information regulator 1 homolog 1), an epigenetic regulator from the sirtuin family, play a crucial role in development of chemoresistance in AML, which enhances the overexpression of multidrug-resistance-associated transporters, including MDR1 and MRP1, making cancer cells resistant to the conventional chemotherapy [8,9,10,11].