Since SIRT1 is an oncogene involved in regulating chemoresistance and proliferation in AML cells [9,26,27,28,29], we demonstrated using quantitative real-time reverse transcriptase–polymerase chain reaction (qRT-PCR) and immunofluorescence assays that SC alone or in combination with Ara-C significantly decreased SIRT1 expression compared to other experimental groups (Figure 4A). Here, SIRT1 is linked to acute myeloid leukemia.