This state is reminiscent to non-alcoholic steatohepatitis (NASH) because of the downregulation of PPARα-related lipid metabolism and inhibition of glycogenesis (GYS2 down), which suggests glucose release or glycolysis (G6P and G6PC3 up, G6PD down). The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.