Upon stabilisation, HIF-1α induces a suite of genes involved in angiogenesis (Figure 2B, VEGF, ANGPT2, SDF1, and SCF [11]), glucose metabolism (Figure 2A, GLUT1), and invasion (Figure 2D, MMPs), all of which are crucial to tumour progression and metastatic competence [30,31]. Here, CXCL12 is linked to neoplasm.