The evidence linking ZIKV to schizophrenia is supported by transcriptomic data showing dysregulation of psychiatric disorder-associated genes, including those implicated in schizophrenia, such as nuclear receptor subfamily 4 group A member 2 (NR4A2) and neuroligin 1 (NLGN1), following ZIKV infection. This evidence concerns the gene NR4A2 and Zika virus infectious disease.