ACE2 and schizophrenia: It has also been observed that angiotensin-converting enzyme 2 (ACE2), the host receptor mediating the entry of both SARS-CoV and SARS-CoV-2, exhibits relatively elevated expression in cerebral areas engaged in schizophrenia, including glutamatergic, dopaminergic, and serotonergic nuclei, the lateral ventricles, and the substantia nigra, despite its generally low expression in the central nervous system.