EIF2AK2 and schizophrenia: Therefore, the administration of polyriboinosinic-polyribocytidylic acid in animal models induces the upregulation of interferon-induced gene expression within the dentate region of the hippocampus, including interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), protein kinase R (Prkr), MX dynamin-like GTPase 2 (Mx2), and interferon regulatory factor 7 (Irf7), while producing behavioural impairments in sensorimotor filtering and novel object identification that parallel the core features of schizophrenia.