The aim of the present study was to analyze the genetic association, as well as the interaction, of SNPs of PNPLA3 (rs738409 and rs2294918), GCKR (rs780094), MBOAT7 (rs641738), NCAN (rs2228603), and TM6SF2 (rs58542926) with the risk of development of HCC in a Mexican population. Here, GCKR is linked to hepatocellular carcinoma.