In regard to SNPs of PNPLA3, the homozygous genotype GG of rs738409 was associated with high risk of developing HCC under codominant model (OR (95% CI) = 4.5 (2.3–8.9), p < 0.0001), dominant model (OR (95% CI) = 2.8 (1.5–5.5), p = 0.001), and recessive model (OR (95% CI) = 2.7 (1.8–4.1), p < 0.0001). The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.