PNPLA3 and Cirrhosis: The rs738409G (I148M) of PNPLA3 is a genetic variant that has been consistently linked to elevated liver enzymes, hepatic triglyceride accumulation (steatosis), and more aggressive disease manifestations, including non-alcoholic steatohepatitis, advanced fibrosis, cirrhosis, and even hepatocellular carcinoma with different etiologies [21,22].