The presence of a non-synonymous variant of TM6SF2 (rs58542926) results in a misfolded protein, with accelerated degradation and reduced function, leading to retention of low-density lipoproteins (VLDL), promoting hepatic steatosis, inflammation, and fibrosis, accelerating the development of HCC. The gene discussed is TM6SF2; the disease is hepatocellular carcinoma.