TM6SF2 and hepatocellular carcinoma: Other SNPs of genes related to altered hepatic lipid metabolism have also been associated with HCC, such as: rs58542926 (p.Glu167Lys) of the Transmembrane 6 superfamily member 2 (TM6SF2) [16], rs780094 (intronic variant) of Glucokinase regulator (GCKR) [17,18], rs2228603 (p.Pro92Ser) of Neurocan (NCAN) [19], and rs641738 (p.Glu17Val) of Membrane bound O-acyltransferase domain containing 7 (MBOAT7) [20].