ASCL2 and adenoma: In a multi-omic study conducted by Chen et al., which compared conventional adenomas with serrated lesions, single-cell transcriptomic analysis suggested that adenomas are derived from cells with an intestinal stem cell signature (expressing LGR5, OLFM4, ASCL2), whereas serrated lesions originate from differentiated absorptive cells, such as goblet cells (expressing TFF3 and MUC2).