As membrane proteins, EphB4 (highly expressed in prostate cancer [24], breast cancer [25], head and neck cancer [26], colon cancer [27], esophagus cancer [28], skin cancer [29], pancreatic cancer [30], lung cancer [31], etc.), CLDN1 (highly expressed in ovarian cancer [32], lung cancer [33], liver cancer [34], colorectal cancer [35], oral squamous cell carcinoma [36], melanoma [37], etc.), and LAT1 (highly expressed in melanoma, lung cancer, and colon cancer [38]) were candidates. The gene discussed is EPHB4; the disease is melanoma.