SPARC and breast cancer: ROBO1 is highly expressed in breast cancer, pancreatic ductal adenocarcinoma [39], hepatocellular carcinoma [40], etc. Furthermore, as intracellular proteins, FOXM1 is highly expressed in breast cancer [41] and hepatocellular carcinoma [42], and SPARC is highly expressed in breast cancer [43], glioblastoma [44], melanoma, etc. [45,46].