Further analysis of 14 identical cases of primary CRC and liver metastases (Figure S2) showed that while the median expression levels of FOXM1 and SPARC were significantly decreased in liver metastases, the median expression levels of CLDN1, EphB4, LAT1, HSP105α, ROBO1, and HLA class I were only slightly reduced and not statistically significant. This evidence concerns the gene SPARC and colorectal carcinoma.