HLA-A and colorectal carcinoma: Regarding the deficiency of HLA-ABC in CRC, they performed a comprehensive analysis with five large cohort studies of CRC and reported that the percentage of CRC with total HLA (HLA-ABC) deficiency was 16%, and 84% of CRC cases expressed either HLA-A, B, or C. Using whole exome sequencing (WES) analysis, Li C et al. also reported the positive incidence of LOH in HLA locus in primary CRC and CRCLM [71].