Similarly, severe LIS1-lissencephaly patient organoids (Grade 1) showed a notable decrease in Wnt signaling, which disrupted the architecture of the ventricular zone (VZ) niche [75]—an essential region in the cortical niche where neural stem cells proliferate and initiate cortical neurogenesis—and subsequently reduced the expression of cell adhesion molecules due to abnormal microtubule dynamics [74]. Here, PAFAH1B1 is linked to Lissencephaly.