CRK and myelodysplastic syndrome: Interestingly, the reduced expression of METTL16 (methyltransferase-like protein 16), an m6A (N6-methyladenosine) RNA methyltransferase, decreased cell migration of the patient-derived MDS cell line GM06097 (Figure 1) [61], but the overexpression of METTL16 increased cell migration based on a wound healing assay, suggesting that METTL16 may also affect neuronal migration as observed for PAFAH1B1 [90], CRK [67] and YWHAE [25] haploinsufficiency.