SPRY4 and Kallmann syndrome: For this purpose, normal human lung fibroblasts WI38 were infected with adenoviruses, which contain the coding sequence of either a control protein (luciferase and/or cyan florescent protein CFP), the most commonly expressed, unaltered version of Spry4 (Spry4wt) or the Spry4 protein altered by the investigated mutation identified in Kallmann syndrome (Spry4K177R).