For this purpose, normal human lung fibroblasts WI38 were infected with adenoviruses, which contain the coding sequence of either a control protein (luciferase and/or cyan florescent protein CFP), the most commonly expressed, unaltered version of Spry4 (Spry4wt) or the Spry4 protein altered by the investigated mutation identified in Kallmann syndrome (Spry4K177R). This evidence concerns the gene CFP and Kallmann syndrome.