In recent work by Carvajal and coauthors, evidence that the mouse distal colon upregulates Reelin production in response to dextran sodium sulfate (DSS)-colitis through DNA Methyltransferase 1 (DNMT1)-dependent hypomethylation of the gene promoter region and that Reelin offers protective effects against colitis has been reported [73]. Here, DNMT1 is linked to colitis.