PubMed search terms included “ocular”, “retinopathy”, “maculopathy”, “Alzheimer disease”, “neurodegeneration”, “parainflammation”, “gut-brain-axis”, “gut-brain-eye-axis”, “inflammageing”, “amyloid-β”, “tau protein”, “personalized medicine”, “biological markers”, and “Psycho-Neuro-Endocrine-Immunology circuit”, either alone or in combination with the search term “Reelin” (accessed on 19 June 2025). The gene discussed is MAPT; the disease is Alzheimer disease.