One of relevance was HSD17B10 (Aβ-binding alcohol dehydrogenase, ABAD) which is involved in isoleucine and neurosteroid metabolism, is up-regulated in Alzheimer’s disease, and has been shown to interact with Aβ peptide but it is unclear whether they have concerted or independent roles in AD pathogenesis [114]. Here, HSD17B10 is linked to early-onset autosomal dominant Alzheimer disease.