Of interest, single synapse analyses of the hippocampus of individuals with AD and high Tau had significantly increased expression of the two enzymes that catalye creatine synthesis: glycine amidinotransferase (GATM, alias AGAT) and guanidinoacetate N-methyltransferase (GAMT) [344], probably indicating a drive for creatine production. This evidence concerns the gene GATM and Alzheimer disease.