Recent findings suggest that in a CRC cell model with LS174T cells, IL-22, through Erk1/2-mediated downstream regulation of its target, the p90 ribosomal S6 kinase (p90RSK), activates c-Jun and transcriptional changes in Tripartite motif containing 15 (TRIM15) and Stomatin (STOM), well-known for its modulatory actions of acid-sensitive ion channels. The gene discussed is STOM; the disease is colorectal carcinoma.