Although most data suggest that IL-20 has protumor effects, it has been reported that IL-20 inhibits cyclooxygenase-2 (COX-2)/prostaglandin-E2 (PGE2) production in NSCLC by limiting COX-2-mediated angiogenesis in vitro [102]. The gene discussed is PTGS2; the disease is non-small cell lung carcinoma.