By using adenovirus vector expressing IL-24 (Ad.IL-24), it has been demonstrated that IL-24 binds ER stress markers, BiP/GRP78 and Sigma 1 Receptor (σ1), triggering mitochondrial dysfunction, ROS production, and apoptosis in human prostate cancer cell lines [97,98,99]. The gene discussed is HSPA5; the disease is prostate carcinoma.