For example, IL-20 signaling in tumor or stromal cells can drive the expression of Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor Beta (TGF-β), and Programmed Death-Ligand 1 (PD-L1), which promote immune evasion, angiogenesis, and a tolerogenic microenvironment. This evidence concerns the gene CD274 and neoplasm.