NFKB1 and colitis: Lentinan acts as a prebiotic, and when damage is induced by dysbiosis, lentinan is able to reduce its effects because of the decreased NF-κB expression, increased number of actinobacteria, and decrease in the harmful proteobacteria and epsilon bacteremia, which has been linked to causing colitis due to being increased in numbers of affected IBD individuals [12,13].