ADAM17 and obesity due to melanocortin 4 receptor deficiency: Dou et al. found that age and obesity are associated with increased ADAM17 enzyme activity in human mediastinal AT blood vessels and adipocytes [44], which aligns with the present data, showing an increase in ADAM17 protein expression in subcutaneous AT from older individuals with obesity, a condition that parallels the enhanced expression of ADAM17 mRNA in the subcutaneous AT of obese mice [45].