The activation of AGE–RAGE or AGE–RAGE stress in almost all cardiovascular diseases was associated with cross-linking with collagen, the generation of oxidative stress, reduction of NO, and increased expression of endothelin-1, TGF-β, inflammatory cytokines, and cell adhesion molecules, as well as the activation of sympathetic activity and NF-kβ [139,140,141]. Here, AGER is linked to cardiovascular disorder.