RB1 and neoplasm: Watanabe and collaborators analyzed 50 tumor-related genes in 100 surgical samples, finding that 8 genes are mutated at high frequency, namely PTEN (57%), PIK3CA (51%), TP53 (30%), KRAS (23%), CTNNB1 (21%), FBFR2 (13%), FBXW7 (10%), and RB1 (9%), identifying them as EC driver genes [38].