In the first part of the current study, molecular docking studies were employed to assess the binding affinities of rutin and quercetin, as the two most abundant bioactive compounds in G. verum extract, toward key molecular targets involved in the etiopathogenesis of psoriasis, including interleukin receptors, JAK2, MAPK2, NF-κB, and STAT3. The gene discussed is STAT3; the disease is psoriasis.