PRKCI and breast carcinoma: Therefore, this study investigates the role of PKC-ι in breast cancer by utilizing a small molecule inhibitor 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1S) specific to PKC-ι.