Their effects are exerted in multiple ways, including HER2 protein downregulation, prevention of HER2-containing heterodimer formation, initiation of G1 cell cycle arrest by induction of the p27 tumor suppressor, prevention of HER2 cleavage, inhibition of angiogenesis, and induction of immune mechanisms (Figure 1) [20]. This evidence concerns the gene ERBB2 and neoplasm.