Therefore, this study aimed to investigate the association of variants in exon 1 (non-coding amino acid sequence), intron 2, and intron 7 of the LPL gene with Body Mass Index (BMI) and variations in lipid levels including TG, total cholesterol (TC), and low-density lipoprotein (LDL), as well as HDL, which are commonly presented with dyslipidemia in the Kuwaiti population. The gene discussed is LPL; the disease is metabolic syndrome.