TNC and Alzheimer disease: The single-cell sequencing results for an AD mouse model show that low GFAP expression in AD is mainly associated with Gpc5, Luzp2, Lsamp, Trpm3, Slc7a10, and others [15], while the high GFAP state in AD is primarily associated with Apoe, Clu, Ckb, Cpe, Gpm6b, CD44, TNC, HSPB1, HSP90AA1, SLC1A2, SLC1A3, GLUL, SLC6A11, NRXN1, CADM2, PTN, GPC5, and others [15,26].