IL3 and Alzheimer disease: The deletion of IL3 leads to the decreased expression of Apoe, as well as the inhibition of the expression of genes associated with AD and tissue repair (Spp1, Dkk2, Gpnmb), and microglial immune responses (Clec7a, Igf1, Itgax, Lyz2, Mamdc2, Actr3b, Trem3, Trem1, Ctsg, Ctsw, Cd200r4, Clec4e, Cxcr4, Cxcr6, IL27ra) and genes (Ccl8, Ccl5, Hpse, Lox, Mmp9, Mmp12, Mmp8, Mmp25) that are essential for cell motility, extracellular matrix remodeling, and lysis [118].