ENO2 and neoplasm: The network (11 nodes, 45 edges, PPI enrichment p-value = 5.81 × 10−14) was clustered into four groups, with Cluster 1 (KRT19, KRT8, KRT18, and EPCAM) linked to cytoskeletal organization and adhesion, Cluster 2 (CEACAM5 and AFP) to tumor progression, Cluster 3 (DSP and ENO2) to cytoskeletal and metabolic processes, and Cluster 4 (C17orf97 and PROM1) to stemness (Table 2).