Tau hyperphosphorylated at different sites, such as threonine 181 (p-tau181), threonine 217 (p-tau217), or threonine 231 (p-tau231), can be detected in the CSF [57] of AD patients and differentiated from non-AD dementias and cognitively unimpaired individuals [47]. This evidence concerns the gene MAPT and Alzheimer disease.