Core 1 biomarkers consist of amyloid-PET, cerebrospinal fluid (CSF) Aβ1-42/Aβ1-40 ratio, CSF phosphorylated (p)-tau181/Aβ1-42, CSF total tau/Aβ1-42, or combinations of these, and these markers are considered to be diagnostic of AD [20]. The gene discussed is MAPT; the disease is Alzheimer disease.