Beyond exhaustion, T cells exist in multiple states including naive (CD45RA+CCR7+), central memory (CD45RO+CCR7+), effector memory (CD45RO+CCR7−), and terminally differentiated effector (CD45RA+CCR7−) populations, each with distinct capacities for tumor control [24,25,26]. The gene discussed is CCR7; the disease is neoplasm.