M1, induced by interferon-gamma (IFN-γ) and lipopolysaccharide (LPS), express high levels of inducible nitric oxide synthase (iNOS), interleukin (IL)-12, and tumor necrosis factor-alpha (TNF-α), promoting anti-tumor immunity through direct cytotoxicity and T cell activation [27,28,29]. Here, NOS2 is linked to neoplasm.