Although studies on whether TSC microglia independently generate an inflammatory response before seizures are lacking, the direct activation of BV2 microglia mTORC1 induces the expression of the pro-inflammatory factors TNF-α, IL-6, and HMGB1 and decreases the expression of the anti-inflammatory factors TGF-β and IL-10. This evidence concerns the gene IL10 and tuberous sclerosis.