ACE and myocardial infarction: Defining the cardioprotective role of SH and non-SH-containing ACE inhibitors during MI in rats, researchers have found that ACE inhibitors can protect the heart against I/R injury and these effects of captopril were attributed to the decreased production of Ang II due to ACE inhibition and the increased release of myocardial prostacyclin (PGI2) [298].