KRIT1 and colorectal carcinoma: In addition, SW480 CRC cell line-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by KRIT1 suppression and β-catenin activation in recipient endothelial cells [133], while M2 macrophage-derived exosomes containing miR-21-5p enhance CRC cell migration and invasion in the SW48 and SW480 cell lines and in vivo [134].