MAPK8 and acute leukemia: detoxification of endogenous and exogenous toxic compounds by glutathione-dependent conjugation or by acting as a ligandin [8]; binding the mitogen-activated protein (MAP) kinases JNK1, ASK1, and MEKK1 [2,14]; monomeric GST P acting as an inhibitor of C-jun N-terminal kinase [15]; deletion of GST P1 gene-risk factor of acute leukemia [16]