MAP3K1 and acute leukemia: conjugation of prostaglandin A2 and prostaglandin J2 with glutathione (GST M1a-1a) [19]; participating in the formation of novel hepoxilin regioisomers [20]; GST M1: metabolism of isothiocianates (most efficient, among GSTM1, GSTP1, GSTA1, and GSTM4) [21]; binding the mitogen-activated protein (MAP) kinases JNK1, ASK1, and MEKK1 [2,14,22]; deletion of GST M1 gene-risk factor of acute leukemia [16]