Huaxin Zhu and colleagues highlighted RHAMM’s upregulation in gliomas, forming a crucial endogenous RNA (ceRNA) network involving HEELPAR lncRNA, hsa-let-7i-5p miRNA, and Ribonucleotide reductase2 (RRM2), significantly affecting glioma biology [77]. The gene discussed is RRM2; the disease is central nervous system cancer.